There are no human studies demonstrating that minoxidil causes collagen depletion or wrinkles as a side effect (and there are many studies of minoxidil effects on humans).Click to see full answer. Besides, does Minoxidil age your face?Minoxidil and Facial Aging: Yes or No, …or we don’t know? There is currently a great buzz on the internet world that topical minoxidil affects collagen synthesis and affects facial skin by promoting facial aging. To date, there is no good evidence in the medical literature that minoxidil promotes aging of the face.Also Know, does Minoxidil decrease collagen? Minoxidil inhibits collagen, which prevents healthy skin, more mature hairs, causes dark eyes etc. Stick with 0.5mm and you’ll go deep enough to stimulate collagen and short enough to reduce risk of damage or scarring. Also asked, does Minoxidil affect skin? Depending on the formulation, the most common side effect of minoxidil is skin irritation at or near the application site. In some cases, minoxidil users can develop a skin rash or experience a mild burning feeling after using minoxidil spray or foam.Does Minoxidil affect blood pressure?Minoxidil is used to control high blood pressure. Minoxidil can make your heart beat more quickly and cause your body to keep more fluid than normal. You will be prescribed other medicines to help control this. Minoxidil can also cause fine facial hair to darken and become thicker in texture.