Yes, a 22 will kill one, and it will penetrate the “armor” if fired from under about 15 yards. Goes in, usually does not come out.Click to see full answer. Besides, can you shoot a armadillo?Armadillos are nocturnal and nomadic, so shooting is usually not practical. However, if the opportunity arises, you may shoot them with either a rimfire or shotgun loaded with No. If armadillos are unusually active in a golf course or cemetery, they can sometimes be spotlighted and shot at night.One may also ask, can a bullet penetrate an armadillo? Evidently an armadillo shell can cause a 38 bullet to deflect instead of puncturing it. It is possible that such an impact could still kill the armadillo, since men wearing bulletproof vests suffer significant bruising when shots enter the vest. One may also ask, what is the best gun to kill a armadillo? A magnum . 177 air rifle (>1000 ft/sec) will penetrate the shell and kill them. They’ll probably run off a bit, but if you place the shot carefully, no more armadillo.Will a 22 short kill you?A . 22 caliber bullet can kill you instantly if you are hit in the right spot or kill you slowly if you are hit in a spot that you will bleed to death. I have had the misfortune of being hit by 3 different rounds, the . 22 LR, .